Zhigang Guo Selected Research

Flap Endonucleases

3/2021	Lung cancer: progression of heat shock protein 70 in association with flap endonuclease 1 protein.
1/2020	MicroRNA-140 impedes DNA repair by targeting FEN1 and enhances chemotherapeutic response in breast cancer.
12/2019	Inhibition of AKT Sensitizes Cancer Cells to Antineoplastic Drugs by Downregulating Flap Endonuclease 1.
4/2017	Interacting partners of FEN1 and its role in the development of anticancer therapeutics.
1/2017	FEN1 promotes tumor progression and confers cisplatin resistance in non-small-cell lung cancer.
12/2016	Targeting DNA Flap Endonuclease 1 to Impede Breast Cancer Progression.
7/2011	Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancer.
7/2008	Nucleolar localization and dynamic roles of flap endonuclease 1 in ribosomal DNA replication and damage repair.

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Zhigang Guo Research Topics

Disease

35	Neoplasms (Cancer) 01/2022 - 10/2007
13	Atherosclerosis 02/2022 - 10/2014
11	Inflammation (Inflammations) 01/2022 - 01/2013
8	Breast Neoplasms (Breast Cancer) 01/2022 - 06/2014
7	Glioma (Gliomas) 09/2020 - 08/2016
6	Genomic Instability 01/2020 - 07/2008
5	Coronary Artery Disease (Coronary Atherosclerosis) 01/2022 - 01/2018
5	Neoplasm Metastasis (Metastasis) 01/2020 - 10/2007
4	Atherosclerotic Plaque (Atheroma) 01/2022 - 12/2014
4	Fibrosis (Cirrhosis) 12/2021 - 01/2016
4	Cardiovascular Diseases (Cardiovascular Disease) 12/2021 - 01/2015
3	Coronary Stenosis (Coronary Artery Stenosis) 01/2022 - 01/2019
3	Lung Neoplasms (Lung Cancer) 03/2021 - 01/2017
3	Obesity 01/2021 - 08/2018
3	Hypertension (High Blood Pressure) 01/2021 - 04/2020
3	Hypoxia (Hypoxemia) 10/2020 - 01/2016
3	Carcinogenesis 01/2020 - 08/2016
3	Colorectal Neoplasms (Colorectal Cancer) 01/2018 - 02/2014
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2018 - 01/2017
2	Bites and Stings (Sting) 07/2022 - 01/2022
2	Pathologic Processes 01/2022 - 09/2016
2	Chest Pain (Chest Pains) 01/2022 - 05/2019
2	Ovarian Neoplasms (Ovarian Cancer) 12/2021 - 10/2007
2	Aortic Dissection 09/2021 - 06/2021
2	Infections 04/2021 - 01/2019
2	Necrosis 01/2020 - 01/2020
2	Glioblastoma (Glioblastoma Multiforme) 01/2020 - 01/2019
2	Brain Neoplasms (Brain Tumor) 01/2020 - 11/2018
2	Uterine Cervical Neoplasms (Cancer of the Cervix) 12/2019 - 01/2018
2	ST Elevation Myocardial Infarction 05/2019 - 01/2017
2	Trigeminal Neuralgia (Tic Douloureux) 01/2019 - 01/2016
2	Hemorrhage 01/2017 - 04/2006
1	Coronary Vasospasm (Coronary Artery Vasospasm) 12/2022
1	Leukemia 06/2022
1	Dysbiosis 01/2022
1	Diabetes Mellitus 01/2022
1	Acute Coronary Syndrome 01/2022

Drug/Important Bio-Agent (IBA)

10	Proteins (Proteins, Gene)FDA Link 01/2022 - 07/2011
10	Pharmaceutical PreparationsIBA 01/2022 - 01/2018
10	CholesterolIBA 01/2022 - 10/2014
9	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 07/2008
8	Flap EndonucleasesIBA 03/2021 - 07/2008
6	LipidsIBA 02/2022 - 01/2018
6	Biological ProductsIBA 01/2022 - 02/2011
6	Apolipoproteins E (ApoE)IBA 01/2022 - 01/2018
6	oxidized low density lipoproteinIBA 01/2022 - 10/2014
6	Biomarkers (Surrogate Marker)IBA 01/2020 - 02/2014
5	Cisplatin (Platino)FDA LinkGeneric 12/2019 - 01/2017
4	Long Noncoding RNAIBA 10/2021 - 08/2016
3	CytokinesIBA 01/2022 - 10/2016
3	omega-Chloroacetophenone (Mace)IBA 01/2022 - 01/2015
3	AntioxidantsIBA 10/2021 - 03/2017
3	Antineoplastic Agents (Antineoplastics)IBA 01/2021 - 01/2018
3	Triglycerides (Triacylglycerol)IBA 01/2021 - 01/2021
3	Proliferating Cell Nuclear Antigen (PCNA)IBA 10/2020 - 07/2011
3	Messenger RNA (mRNA)IBA 01/2020 - 08/2016
3	CurcuminIBA 01/2020 - 01/2013
3	MicroRNAs (MicroRNA)IBA 01/2020 - 08/2016
3	ErbB Receptors (EGF Receptor)IBA 10/2019 - 10/2007
3	HDL LipoproteinsIBA 10/2016 - 01/2002
3	CXCR4 Receptors (CXCR4 Receptor)IBA 06/2008 - 10/2007
2	Chimeric Antigen ReceptorsIBA 06/2022 - 01/2021
2	Epidermal Growth Factor (EGF)IBA 01/2022 - 10/2007
2	Proline (L-Proline)FDA Link 01/2022 - 01/2018
2	MethyltransferasesIBA 01/2022 - 10/2019
2	CamptothecinIBA 01/2022 - 01/2018
2	Serine (L-Serine)FDA Link 01/2022 - 01/2018
2	trimethyloxamine (trimethylamine N-oxide)IBA 01/2022 - 01/2022
2	InterferonsIBA 12/2021 - 01/2020
2	CollagenIBA 12/2021 - 01/2016
2	Therapeutic UsesIBA 08/2021 - 01/2017
2	RNA (Ribonucleic Acid)IBA 04/2021 - 08/2016
2	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 01/2021
2	LDL CholesterolIBA 01/2020 - 08/2015
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2020 - 01/2017
2	Fluorouracil (Carac)FDA LinkGeneric 01/2020 - 01/2018
2	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2020 - 01/2016
2	Arginine (L-Arginine)FDA Link 05/2019 - 01/2016
2	Temozolomide (Temodar)FDA LinkGeneric 01/2019 - 11/2018
2	Serum Amyloid P-ComponentIBA 01/2018 - 01/2016
2	NucleotidesIBA 06/2009 - 01/2002
2	LigandsIBA 06/2008 - 10/2007
2	Chemokine CXCL12IBA 06/2008 - 10/2007
1	Interleukin-1 (Interleukin 1)IBA 07/2022
1	Interleukin-18 (Interleukin 18)IBA 07/2022
1	Galectin 3 (LGALS3)IBA 01/2022
1	SulfotransferasesIBA 01/2022
1	Mixed Function Oxygenases (Monooxygenases)IBA 01/2022
1	Interferon Type IIBA 01/2022
1	N-methyladenosineIBA 01/2022
1	Choline (Choline Chloride)IBA 01/2022
1	4,6-dinitro-o-cresol (DNOC)IBA 01/2022
1	Phospholipid Hydroperoxide Glutathione PeroxidaseIBA 01/2022

Therapy/Procedure

19	Therapeutics 06/2022 - 10/2007
5	Drug Therapy (Chemotherapy) 12/2021 - 01/2017
2	Off-Pump Coronary Artery Bypass (Coronary Artery Bypass, Off Pump) 12/2022 - 04/2006
2	Percutaneous Coronary Intervention 01/2022 - 05/2019
2	Transcatheter Aortic Valve Replacement 08/2021 - 07/2020
2	Electrocoagulation (Electrocautery) 01/2019 - 01/2016
1	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 12/2022